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Pretty sure it wasn’t formal.
This is exactly why I’m not a gambler. ;-) I really prefer it when people say things like, “wow, thanks, here have a fiver.”
A little chortle now and then. Keeps things from getting to ‘heavy’.
From the abstract: "By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. "
I guess you owe me five bucks.
It was her all along!
A disease-associated gene desert directs macrophage inflammation through ETS2 https://www.nature.com/articles/s41586-024-07501-1
Abstract
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug development2, highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. Genes regulated by ETS2 were prominently expressed in diseased tissues and more enriched for inflammatory bowel disease GWAS hits than most previously described pathways. Overexpressing ETS2 in resting macrophages reproduced the inflammatory state observed in chr21q22-associated diseases, with upregulation of multiple drug targets, including TNF and IL-23. Using a database of cellular signatures7, we identified drugs that might modulate this pathway and validated the potent anti-inflammatory activity of one class of small molecules in vitro and ex vivo. Together, this illustrates the power of functional genomics, applied directly in primary human cells, to identify immune-mediated disease mechanisms and potential therapeutic opportunities.
Chargers may be found at plugshare.com. L1 and L2 chargers is as simple as plugging a charging cable into a 120v or 240v socket.
By that standard, I’m pretty sure dictionaries were the first LLM. :-D
One could poke around on those sources: https://population.un.org/wpp/Graphs/DemographicProfiles/Line/1832
https://www.oecd.org/els/health-systems/health-data.htm
My understanding is that the largest part of expenditures on health is generally at end of life, at least in developed countries, rather than spending a smaller amount on disease prevention earlier in life, which would be expected to have a larger effect on morbidity and mortality.
EEAGLI looks to be some sort of marketing/ PR firm. shrug
Also not a word about other countries, mostly China and Russia, interfering with US elections. smh.
Sort of the reverse, really. From my perspective it seems we really ignored post viral syndromes, until SARS-CoV-2 and ‘Long Covid’. As researchers have begun looking at Long Covid, they have also been drawn to elucidating other post viral syndromes.
From the BMJ 21 Sept 2022: How “long covid” is shedding light on postviral syndromes https://www.bmj.com/content/378/bmj.o2188
He was really outstanding in Higgs field.
Someone who’s life should not be ‘tldr’d’. https://en.wikipedia.org/wiki/Peter_Higgs
Happy Pi Day! Celebrate Circularity! Ride Bikes! Share Spherical Sonnets! Get around to doing things! 🍕🥧🔴🟠🟡🟢🔵🟣
I would have to agree. Alas, it’s entirely possible that their loss of cognitive function, decreased I.Q., is preventing them from this sort of understanding.
From the article: " Reinfection with the virus contributed an additional two-point loss in IQ, as compared with no reinfection." So yes, there can be a compounding. It’s research like this that makes me want to keep my ‘mask, handwash, neti washing, indoor air filtration, avoid crowds indoors, etc’ policy in place. Sigh.
Think a moment on the connection between Gut and Brain. Consider, especially if your case of La ‘Rona had GI symptoms and/or alterations in sleep patterns, using Prebiotics, e.g. Inulin, Green Banana Flour, and Probiotics (any live cultured foods that taste good to you, e.g. kimchi), the combination of which Pre + Pro = Synbiotics. Lions mane is also a beneficial nutraceutical / food. Exercise, tho’ not of the extreme type, can also benefit cognition.
Agreed, definitely in favor. And those fungi are super handy in breaking down the cell walls of plants.
Green skin and photosynthetic ‘bat wings’. Lunch, just chill out in the sunshine. Can’t have it YET!
Silent Spring, by Rachel Carson (https://en.wikipedia.org/wiki/Silent_Spring), https://archive.org/details/fp_Silent_Spring-Rachel_Carson-1962