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Joined 1 year ago
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Cake day: July 2nd, 2023

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  • You basically just described every rural town, anyplace in the world I have traveled to.

    The younger generation leaves the rural communities for the opportunities found in larger cities and towns. What is left behind is 50+ year olds with no-one to pass the farm onto. Eventually they sell out to someone or go bankrupt. The consolidation of land resources continues.

    My wife and I are some of those the fled the rural hellscape. Those that stayed behind have spent their lives in poverty and ignorance. Both of my grandparents went bankrupt farming and died living with some of their kids in a city.




  • In evolutionary time 20,000 years is not long. With a 25 year average generation time, that’s 800 generations. At an estimated average rate of mutation of 64 per generation that would be 51,200 mutations in that amount of time across 3,117,275,501 base pairs (female).

    This might sound like a lot but only 2% of the human genome encodes proteins. So approximately 1,024 mutations to encoding proteins are possible across 62,345,510 base pairs. However we know that many changes to encoding proteins are conserved so the true number is less.

    This is really a tiny number of mutations. It may take out a few viruses but most of them will still easily infect humans today. The difference between the mutation rate of viruses and our own generation time is why dynamic immune systems have evolved. This allows an organism to develop immunity to the rapidly mutating pathogens without waiting for changes to the DNA.

    As for if this is fear mongering or not: It’s a real probability because of the degree of preservation we have found on carcases in the permafrost. As the permafrost melts these carcases are exposed and transmission is possible.

    Honestly the largest worry would for something like influenza. Able to jump multiple species and recombine into novel new types. We also don’t know how long influenza has been around.


  • Many pathogenic viruses have multiple species as hosts. For example Covid has a long list of species it infects from mink to deer as well a humans. In plants cucumber mosaic virus has over 1200 species it infects and is transmitted by more that 80 aphid species. These are the generally ones we should be the most concerned with emerging from the artic.

    There are viruses that are limited to one species. The only reason we were able to eliminate smallpox was because it was human specific. If it had retained it’s ability to transmit via rodents (it evolve from infecting African rodents) it would likely still be around today.




  • Most companies don’t bother to setup a shell company. International businesses often have an existing distributors in several different countries.

    When one country gets sanctioned a distributor in a neutral country suddenly increases their local sales by the same amount that the one in the sanctioned company used to have.

    I used to work in international business a decade ago. I learned about a customer on the Saudi peninsula who purchased a huge amount of product (1,000x more than their entire market). It was strangely enough to cover Iran not that far away across the Persian Gulf.




  • Just some basics about the company.

    Revenue Income US$8.93 billion (2022)

    Operating income US$4.31 billion (2022)

    Net income US$3.32 billion (2022)

    The bulk of the difference between operating income and net income in a research driven company is the R&D. They are running at 11% just under $1 billion per year. A publically traded company can’t really hide their research costs, only obscure it for the uniformed.

    Their net income is 37% of revenue. So they are paying for over 4 years of research for every year (3 past years plus current gear). So their argument they need the high prices to cover past research costs is pure bullshit. I’d give them the current year and one past year. But 4 years?

    This is pure price gouging for profit over people’s lives. Invalidating their patent is fully justified.




  • My wife worked for an insurance company for most of a decade as the complaint liaison with the states regulating body on insurance.

    Insurance companies in the U.S. come in two types.

    Type A: Rely on repeat business and word of mouth to slowly grow their business. They pay out reasonable and fair amounts based upon the loss. They follow all applicable laws/regulations and operate in good faith. These companies are quick to reject people who have bad histories.

    Type B: Rely on recruiting new customers constantly by excessive advertising or purchasing other smaller companies. Pay out well below the market on anything they can and flat out refuse claims until lawsuits start. These companies routinely break state and federal laws because the fines are less than the profits. These companies prey on the lower income, elderly, and poorly informed. The larger companies have hundreds of brands to give the illusion of choice to the consumer.

    Any amounts of excessive marketing by and insurance company indicates that they are shit. Also research into who owns any the brand they are are marketing. If you recognize the parent company as advertising, they are shit.