Takatakatakatakatak

  • 0 Posts
  • 77 Comments
Joined 1 year ago
cake
Cake day: June 15th, 2023

help-circle




  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976712/

    It’s significant. Biggest effect is on efficacy of drug metabolism. There are many such studies.

    One size does not fit all here owing to differences in expression of metabolising enzymes and drug transport mechanisms.

    No, the Japanese are not aliens but they may require far less of a given drug than a westerner, or far more. This affects the likelihood to experience side effects for any given compound, and their severity.

    It’s fairly ironic to make this change for Japan whilst elsewhere in the world with more racially mixed populations there has been a push in the opposite direction: a recognition that you cannot assume the results of a trial carried out on white male subjects will apply to those of African descent for example.

    It’s not just drug treatments either. There are many aspects of medical care which have suffered from a lack of specificity and systemic bias.







  • It seems like you’ve read enough to get halfway there.

    You should go back and read the source documents and go over what ecohealth alliance were actually doing, and where they were doing it. The funding proposals were extremely detailed, right down to carrying out gain of function research to aerosolise the corona viruses harvested from bats.

    It is almost impossible to immunise bats using droplet transmission and this is the source of the global fuckup.

    At some stage during this process, the modified pathogen from very early stages of developing a corona vaccine FOR BATS (the stated goal of the funding request) it somehow got out of one of the labs involved. (Malice or stupidity, we’ll never know)

    At that stage it would still be fair to call the original escaped variant a VIRUS because it had not yet reached the development stage of being attenuated sufficiently to be called a vaccine, but it was a long way from a wild type variant.

    This lines up with early sequencing of the virus that is widely documented. Those with any scientific integrity have acknowledged from day 1 that there were portions of the sequence that can not occur without human intervention.

    In short, this was all being done with US funding in labs with woefully inadequate safety protocols.

    So long as we are prepared to accept the risk/reward profile of gain of function research being carried out anywhere in the world, the risk of a similar global pandemic will never go away.