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They’re going to get fuuuuuuuuucked.
Poor bastards.
They’re going to get fuuuuuuuuucked.
Poor bastards.
I get a sense about people.
Okay, but are you a lawyer?
Eggs existed long before the chicken, or the species that gave birth to the chicken. What’s in that egg doesn’t matter, when it’s the latest in a long line of eggs, the contents of this egg can’t precede eggs.
To get the new genetic material into cells, they engineered harmless viruses to carry it. Doctors carefully injected a tiny amount of liquid containing the viruses into a part of the children’s inner ears called the cochlea, a spiral-shaped chamber that contains hair cells. The first patient in the trial received the gene therapy in December 2022. Researchers followed the participants, who ranged in age from 1 to 6 years old, for 23 weeks after treatment.
While the gene therapy did not give the children a “normal” level of hearing, they went from not hearing anything under 95 decibels—about as loud as a food processor or motorcycle—to perceiving sounds of around 45 decibels—the level of a typical conversation or the hum of a refrigerator.
“The families are very, very excited,” says Yilai Shu, a head and neck surgeon at the Eye & ENT Hospital of Fudan University and an author on the paper. For some of the parents, it’s the first time they’ve heard their children say “mama” or “baba” (Chinese for “papa”).
Other children in the study had previously received a cochlear implant in one ear and had already learned to speak. In those cases, doctors injected the gene therapy into their other ear. Cochlear implants are surgically implanted devices that stimulate the auditory nerve to provide a sense of sound to its wearer. The implants don’t reproduce natural hearing, though. The resulting sound can be robotic or distorted. And when they’re switched off, the wearer can’t hear at all.
With gene therapy, researchers are aiming to provide a natural sense of hearing. When they followed up with patients after the injection, they turned off the cochlear implants to assess how well the therapy was working in the children.
“They became more engaged and responsive. It’s like a change of personality,” says Zheng-Yi Chen, an associate scientist at Mass Eye and Ear, who co-led the study.
One child’s hearing didn’t improve at all. One explanation, Shu says, is that the child had preexisting immunity to the type of virus used to carry the new gene into the inner ear cells—meaning the treatment would have been destroyed by their immune system before it could take effect. It’s also possible that the dose was too low to be effective, Lustig says.
Several companies are pursuing gene therapies for this same cause of deafness. Boston-based Akouos, which was acquired by Eli Lilly in 2022, has treated two subjects in a clinical trial that began last year. Eli Lilly announced this week that one of those participants, an 11-year-old boy, could hear within 30 days of receiving an otoferlin gene therapy.
And in October, Regeneron’s Decibel Therapeutics in Boston reported improved auditory responses in one patient as part of an ongoing clinical trial. Otovia Therapeutics in China and Sensorion of France are working on similar treatments. The Fudan University trial reported today
Born deaf, the 1-year-old boy had never responded to sound or speech before. But after receiving an experimental treatment injected into one of his ears, he started turning his head when his parents called his name. Five months later, he spoke his first words.
The boy is one of six children with a type of hereditary deafness who are part of a gene therapy trial in China. Five of the children can now hear, according to results reported today in the scientific journal The Lancet. The news follows an announcement this week that yet another child born with profound deafness can hear after receiving a similar treatment developed by US drugmaker Eli Lilly.
“It’s remarkable,” says Lawrence Lustig, a hearing loss expert at Columbia University who was not involved in the trial. “We’ve never had a therapy that restores even partial hearing for someone who’s totally deaf other than a cochlear implant.”
The children were all born with a mutation in a gene that makes a protein needed for hearing called otoferlin. We hear things when sound waves in the air cause the thousands of sensory hair cells in our inner ears to vibrate and release a chemical that relays that information to the brain. Otoferlin is necessary for the release of this chemical messenger. Without it, the ear can’t communicate with the brain.
More than half of hearing loss cases in children are due to genetic causes, and otoferlin mutations account for 1 to 8 percent of those, affecting about 200,000 people worldwide.
The treatment the children received works by delivering a working version of the otoferlin gene to the inner ear. The cells of the inner ear then read this gene and produce the protein. In the US and Europe, a handful of these cutting-edge therapies have been approved, including one for a type of inherited blindness. Given just once, they’re designed to correct disease-causing genes—hopefully permanently.
For the deafness treatment, researchers at the Eye & ENT Hospital of Fudan University in Shanghai collaborated with a team at Mass Ear and Eye, a Harvard-affiliated hospital in Boston.
Surprised nobody has posted Newtonmas. Celebrate a historical figure who had major impacts on our civilization by advancing science, and who was actually born on December 25!
Tolerance was and remains a peace treaty: you be tolerant, and we’ll tolerate you. Once someone opts to break the treaty, they receive no further protection from it.
Alreader, I believe on both android and iphone. I use it at a very low intensity level with red text and black background.
Also if you’re hyper concerned about blue light, get some red-toned laser safety glasses, you can get some that go over existing glasses if you need them, and they will, if any good, cut out basically all blue / green light regardless of what’s going on around you. Recommend putting them on 2h before bed for best results.
Yeah I would definitely recommend using a company if you have the scratch. I’ve done a bunch of uhaul moves and once with a company, and while there were hassles, they were so much lesser with the latter.
Cable used to have no commercials. Then they had some commercials, but less than OTA. Now there’s no difference. Streaming services started out with no commercials, then it was commercials, but you can pay for no commercials. Soon it’ll be pay more, for less commercials, I think there’s a service already doing that? Don’t reward them for this shitty behavior by throwing more money at them.
Which is, of course, why randomized anonymous surveys with large sample sizes show that this is actually a thing for a large number of women who are just too terrified to speak up oh no they don’t, damn. Kind of cuts the legs out from under that sort of “silent majority” argument, which is almost always used to advertise the views of the noisy minority.
Right so, you’d rather have the people who will make it more worse than the ones who will make it less worse. You still are making a choice here, and it is for more worse.
When your options are:
50% dead
100% dead
Having only these options suck, but one of those is clearly worse, and if your tax dollars will be used for one your abstemiousness does the 50% who could have lived no favors.
So, to be clear, you would rather have more genocide than to acknowledge in this imperfect world, sometimes harm reduction is the best that is available to us. Do you think a trump admin would have been counseling Israel not to be flattening the West Bank? Because that’s what the Biden admin has been doing, and I’m pretty sure that a trump admin would be cheering them on and demanding bloodshed, which to me seems worse. And yes, you’d get to feel better about not participating in the system, but your hands would in fact have more blood on them. You just wouldn’t notice it.
Riley Gaines, who tied for fifth behind a number of cis women? Yeah, she looked at her future in sport and decided that grifting was easier and would pay better.
Taylor Silverman, the skateboarder? You want to tell me about the super secret male advantage she lost to? I’m not seeing it. Are you going to claim that banning trans women from chess was reasonable too?
People who are speaking up about this are bigots and sore losers. Trans women don’t win disproportionately, there’s no meaningful advantage, and all anyone ever has are anecdotes, almost all of which fail to check out to any meaningful degree. Riley Gaines didn’t even go down a slot so what the fuck do you want here? Trans women don’t get to compete, regardless of fairness? Because if so, say it with your fuckin chest. Don’t try to pretend it’s about fairness.
So you’re saying one of them makes the world less worse, and is therefore preferable to the one that makes it more worse.
Your second link didn’t load for me. Your first was a propaganda network with a woman complaining about a trans girl being beaten by two cis girls. Ki d of seems like the girl in fourth should have been practicing harder like the girls in first and second did. Your news sources are lying, shading the truth, and using loaded language, to make and keep you angry so you don’t make good decisions in life, and you should consider getting new sources.
It’s not a problem because it’s not happening to any meaningful degree. Trans women continue to be under, not overrepresented in high end sports, because there isn’t a meaningful advantage after a couple of years of HRT. Please provide examples of this problem you claim exists.
Any sufficiently identical copy of me is me. A copy just means there are more me in the universe.